Peptide Database

Peptide NameMegin 2

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Venom / Toxin ▸ General toxin ▸ Toxicity

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC159H237N37O31S2

DescriptionStandard

        FFVLKFLLKWAGKVGLEHLACKFKNWC
    

Molecular Weight3226.94 Da

Isoelectric Point (pI)9.60

Net Charge (pH 7.0)3.83

Net Charge (pH 7.4) 3.53

Charge Density (pH 7.0) 0.1417

GRAVY Index0.55

Hydrophobic Moment 0.59

Boman Index0.27

Instability Index-7.59

Aliphatic Index 101.11

Aromaticity 0.2222

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1090.67

LogP -0.52

H-bond Donors 40.0

H-bond Acceptors 38.0

Rotatable Bonds 106.0

Heavy Atoms 229.0

Ring Count 9.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0362554 VERIFIED: YES

Provenance & Taxonomy

OrganismAmphibian skin [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide21-27

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

RECORD: Rec_0406410 VERIFIED: YES

Provenance & Taxonomy

OrganismAmphibian skin [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide21-27

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetCandida albicans (ATCC 2002)

Activity12.5 μg/mL

MethodMIC

RECORD: Rec_0422643 VERIFIED: YES

Provenance & Taxonomy

OrganismAmphibian skin [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide21-27

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

TargetRabbit red blood cells: 5

RECORD: Rec_0427243 VERIFIED: YES

Provenance & Taxonomy

OrganismMegophrys minor [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus ATCC2592

Activity12.5 μg/mL

MethodMIC

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