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MYP_012238
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Basic Information
Megin 2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
27 amino acids
C159H237N37O31S2
Standard
Sequence
FFVLKFLLKWAGKVGLEHLACKFKNWC
Physicochemical Analysis
3226.94 Da
9.60
3.83
3.53
0.1417
0.55
0.59
0.27
-7.59
101.11
0.2222
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1090.67
-0.52
40.0
38.0
106.0
229.0
9.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0147618 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
21-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID27114317 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27114317/
RECORD: Rec_0164365 VERIFIED: YES
Provenance & Taxonomy
Megophrys minor [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis ATCC 6633
1.5 μg/mL
MIC
PMID27114317 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27114317/
RECORD: Rec_0164730 VERIFIED: YES
Provenance & Taxonomy
Megophrys minor [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC25922
6.25 μg/mL
MIC
PMID27114317 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27114317/
RECORD: Rec_0255304 VERIFIED: YES
Provenance & Taxonomy
Megophrys minor [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
12.5 μg/mL
MIC
RECORD: Rec_0273140 VERIFIED: YES
Provenance & Taxonomy
Megophrys minor [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
21-27
Bio-Activity Profile
Antimicrobial Antifungal Toxicity
at 200 ug/ml, it caused 45.3% hemolysis of hRBC and 50.3% rabbit RBC
~200 μg/mL
HC50
PaperTwo novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor.
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