Peptide Database

Peptide NameUnnamed

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ COX-1 Inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ COX-2 Inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ Lipase inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Lipoxygenase Inhibitory

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC42H61N13O13

DescriptionStandard

        YGNPVGGVGH
    

Molecular Weight956.01 Da

Isoelectric Point (pI)6.74

Net Charge (pH 7.0)-0.15

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) -0.0154

GRAVY Index-0.28

Hydrophobic Moment 0.30

Boman Index0.33

Instability Index3.76

Aliphatic Index 58.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 408.43

LogP -5.11

H-bond Donors 13.0

H-bond Acceptors 14.0

Rotatable Bonds 26.0

Heavy Atoms 68.0

Ring Count 3.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0255651 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-inflammatory COX-2 Inhibitory

TargetCyclooxygenase-2 (COX-2)

Activity16.25 μg/mL

MethodIC50

PaperZ?otek U., Jakubczyk A., Rybczy¨½ska-Tkaczyk K., ?wiek P., Baraniak B., Lewicki S.. Characteristics of new peptides GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT as inhibitors of enzymes involved in metabolic syndrome and antimicrobial potential. Molecules, 25, 2492, 2020. PMID32471271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32471271/

RECORD: Rec_0321879 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Enzyme inhibitory ACE inhibitory

TargetACE

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