MYP_012157
Emericellipsin C
Antimicrobial
▸
Antifungal
Standard
9 amino acids
C35H60N10O13
Standard
PQSAIVASG
828.91 Da
5.96
-0.04
-0.10
-0.0046
0.58
0.07
0.34
69.68
97.78
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
365.68
-5.68
13.0
13.0
25.0
58.0
1.0
9.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0114445
VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ser-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antifungal
A. fumigatus VKM F-37
16 μg/mL
MIC
RECORD: Rec_0160814
VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ser-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antifungal
A. niger 1133 m
32 μg/mL
MIC
RECORD: Rec_0209913
VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ser-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antifungal
A. fumigatus 390 m
16 μg/mL
MIC
RECORD: Rec_0237747
VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ser-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antifungal
Microdilution assays: The MIC values for EmiC were in the 4-8 ug/mL range: A. niger ATCC 16404
32 μg/mL
MIC
RECORD: Rec_0241273
VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ser-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antifungal
A. terreus 497
8 μg/mL
MIC
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