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MYP_012131
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Basic Information
Alyteserin-2a-Sp4
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Standard
16 amino acids
C72H130N18O19
Standard
Sequence
ILGKLLATAAGLLANL
Physicochemical Analysis
1551.91 Da
8.75
0.76
0.55
0.0474
1.60
0.34
0.55
10.80
195.62
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
589.16
-3.28
20.0
20.0
52.0
109.0
0.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0185536 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(7) and Ⓧ (14) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
A549
11.6±2.2 μM
IC50
PaperYu Z, Tang H, Cong W, Gao F, Li H, Hu H, Wang X, He S. Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents. J Pept Sci. 2022 Jul;28(7):e3404 PMID34989078 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34989078/
RECORD: Rec_0249816 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(7) and Ⓧ (14) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
8.5±1.4 μM
IC50
PaperYu Z, Tang H, Cong W, Gao F, Li H, Hu H, Wang X, He S. Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents. J Pept Sci. 2022 Jul;28(7):e3404 PMID34989078 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34989078/
RECORD: Rec_0318234 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(7) and Ⓧ (14) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer Antimicrobial Antibacterial
MDA-MB-231
9.2 μM
IC50
PaperYu Z, Tang H, Cong W, Gao F, Li H, Hu H, Wang X, He S. Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents. J Pept Sci. 2022 Jul;28(7):e3404 PMID34989078 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34989078/
RECORD: Rec_0393961 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(7) and Ⓧ (14) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
U87
10.1±1.6 μM
IC50
PaperYu Z, Tang H, Cong W, Gao F, Li H, Hu H, Wang X, He S. Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents. J Pept Sci. 2022 Jul;28(7):e3404 PMID34989078 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34989078/