Peptide Database

Peptide NameDefensin Lc-def

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Fungicidal activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length74 amino acids

Chemical FormulaC363H577N103O108S9

DescriptionStandard

        MEKKTVAALSFLFIVLFVAQEIAVTEAKTCENLSDSFKGPCIPDGNCNKHCKEKEHLLSGRCRDDFRCWCTRNC
    

Molecular Weight8400.68 Da

Isoelectric Point (pI)7.53

Net Charge (pH 7.0)0.61

Net Charge (pH 7.4) 0.15

Charge Density (pH 7.0) 0.0082

GRAVY Index-0.24

Hydrophobic Moment 0.57

Boman Index-0.07

Instability Index20.89

Aliphatic Index 69.86

Aromaticity 0.0811

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 6000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3423.22

LogP -34.80

H-bond Donors 126.0

H-bond Acceptors 120.0

Rotatable Bonds 283.0

Heavy Atoms 583.0

Ring Count 11.0

Amide Bonds 78.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0272849 VERIFIED: YES

Provenance & Taxonomy

OrganismLens culinaris subsp. culinaris [Bacterium]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Antifungal Non-hemolytic

RECORD: Rec_0389978 VERIFIED: NO

Provenance & Taxonomy

OrganismLens culinaris [Bacterium]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Fungicidal Non-hemolytic Non-ribosomal