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MYP_012061
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Basic Information
KilerFLIP-E
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
23 amino acids
C130H208N48O32S
Standard
Sequence
YGRKKRRQRRRREADFFWSLCTA
Physicochemical Analysis
2987.41 Da
11.62
6.75
6.53
0.2935
-1.67
0.51
-0.74
135.24
25.65
0.1739
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1383.03
-14.05
55.0
40.0
102.0
211.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0303580 VERIFIED: YES
Provenance & Taxonomy
The C-terminal domain of c-FLIP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
No toxicity was observed in epithelial and endothelial cells (HPDE and HUVEC, respectively)
PaperPubMed PMID: 24176852 PMID24176852 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24176852/
RECORD: Rec_0332617 VERIFIED: YES
Provenance & Taxonomy
The C-terminal domain of c-FLIP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
(At 20 μM, 10.4% Trypan blue-negative cells)
PaperPubMed PMID: 24176852 PMID24176852 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24176852/
RECORD: Rec_0335274 VERIFIED: YES
Provenance & Taxonomy
The C-terminal domain of c-FLIP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HCT 116 (At 20 μM, about 70% Trypan blue-negative cells)
PaperPubMed PMID: 24176852 PMID24176852 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24176852/
RECORD: Rec_0353042 VERIFIED: YES
Provenance & Taxonomy
The C-terminal domain of c-FLIP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HCT 115 (At 20 μM, 40% Trypan blue-negative cells)
PaperPubMed PMID: 24176852 PMID24176852 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24176852/
RECORD: Rec_0401625 VERIFIED: YES
Provenance & Taxonomy
The C-terminal domain of c-FLIP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
LNCaP (At 20 μM, about 30% Trypan blue-negative cells)
PaperPubMed PMID: 24176852 PMID24176852 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24176852/
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