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MYP_012011
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Basic Information
Oh-defensin (O. hainana defensin; spiders, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
52 amino acids
C240H392N62O63S9
Standard
Sequence
MLCKLSMFGAVLGVPACAIDCLPMGKTGGSCEGGVCGCRKLTFKILWDKKFG
Physicochemical Analysis
5442.64 Da
8.88
3.44
3.12
0.0662
0.57
0.45
0.24
38.95
82.50
0.0769
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1956.47
-15.90
74.0
76.0
182.0
374.0
7.0
51.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0231851 VERIFIED: YES
Provenance & Taxonomy
Chinese bird [Animal]; Arthropoda [Animal]
Defensin
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-31; 17-36; 21-38
Paclitaxel conjugation
Bio-Activity Profile
Antimicrobial
PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0266991 VERIFIED: YES
Provenance & Taxonomy
Ornithoctonus hainana [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
tested strains (MIC: Gram-positive Staphylococcus aureus 1.25 ug/ml; Bacillus cereus 25; Gram-negative Escherichia coli 1.25; B. dysenteriae, 1.25; Pseudomonas aeruginosa, 5 ug/ml
PaperA defensin-like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana
RECORD: Rec_0289098 VERIFIED: YES
Provenance & Taxonomy
Ornithoctonus hainana [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa
5 μg/mL
MIC
PMID21538709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21538709/
RECORD: Rec_0329477 VERIFIED: YES
Provenance & Taxonomy
Haplopelma hainanum [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperJ Pept Sci. 2011 Jul;17(7):540-4. | http://www.ncbi.nlm.nih.gov/pubmed/21538709 PMID21538709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21538709/
RECORD: Rec_0386738 VERIFIED: YES
Provenance & Taxonomy
Haplopelma hainanum [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
PMID21538709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21538709/
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