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MYP_012011
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Basic Information
Oh-defensin (O. hainana defensin; spiders, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
52 amino acids
C240H392N62O63S9
Standard
Sequence
MLCKLSMFGAVLGVPACAIDCLPMGKTGGSCEGGVCGCRKLTFKILWDKKFG
Physicochemical Analysis
5442.64 Da
8.88
3.44
3.12
0.0662
0.57
0.45
0.24
38.95
82.50
0.0769
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1956.47
-15.90
74.0
76.0
182.0
374.0
7.0
51.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0056954 VERIFIED: YES
Provenance & Taxonomy
Ornithoctonus hainana [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
1.25 μg/mL
MIC
PMID21538709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21538709/
RECORD: Rec_0100386 VERIFIED: YES
Provenance & Taxonomy
Ornithoctonus hainana [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
1.25 μg/mL
MIC
PMID21538709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21538709/
RECORD: Rec_0132999 VERIFIED: YES
Provenance & Taxonomy
Ornithoctonus hainana [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
1.25 μg/mL
MIC
PMID21538709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21538709/
RECORD: Rec_0146766 VERIFIED: YES
Provenance & Taxonomy
Ornithoctonus hainana [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus cereus
25 μg/mL
MIC
PMID21538709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21538709/
RECORD: Rec_0184525 VERIFIED: YES
Provenance & Taxonomy
Ornithoctonus hainana [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus dysenteriae
1.25 μg/mL
MIC
PMID21538709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21538709/
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