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MYP_011955
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Basic Information
Gageostatin B
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
7 amino acids
C38H67N7O12
Standard
Sequence
ELLVDLL
Physicochemical Analysis
813.98 Da
4.05
-2.16
-2.33
-0.3089
1.77
0.51
0.53
-12.90
264.29
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
312.52
0.49
10.0
10.0
27.0
57.0
0.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0177537 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
1423
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Lipidation
lipid: 3-beta-hydroxy-9,11-dimethyltridecanoic acid, C15 fatty acid; Gageostatin C: lipid: (E)-7,9-dimethylundec-2-enoic acid, C13 fatty acid chain
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
pathogenic fungi Rhizoctonia solani, Botrytis cinerea and C. acutatum
4-32 μg/mL
MIC
PaperGageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis.
RECORD: Rec_0193847 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antifungal
Newcastle Disease Virus (NDV)
PMID24492520;30973929;30068648;17101680 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24492520/
RECORD: Rec_0193863 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antifungal
Human gastric cancer NUGC-3
10.5 μg/mL
IC50
PMID24492520;30973929;30068648;17101680 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24492520/
RECORD: Rec_0201279 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
1423
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-β-hydroxy-11-methyltridecanoic
-
Bio-Activity Profile
Antimicrobial Anticancer
NCI-H23
11.2 μg/mL
IC50
PMID24492520 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24492520/
RECORD: Rec_0202823 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antifungal
Human lung adenocarcinoma NCI-H23
11.2 μg/mL
IC50
PMID24492520;30973929;30068648;17101680 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24492520/
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