Peptide Database

Peptide NameToxin HmTx2

Function Ontology

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC213H309N53O58S7

DescriptionStandard

        ECRYFWGECNDEMVCCEHLVCKEKWPITYKICVWDRTF
    

Molecular Weight4764.51 Da

Isoelectric Point (pI)5.09

Net Charge (pH 7.0)-2.13

Net Charge (pH 7.4) -2.45

Charge Density (pH 7.0) -0.0560

GRAVY Index-0.33

Hydrophobic Moment 0.35

Boman Index-0.03

Instability Index21.23

Aliphatic Index 53.68

Aromaticity 0.1842

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1794.25

LogP -9.74

H-bond Donors 69.0

H-bond Acceptors 64.0

Rotatable Bonds 151.0

Heavy Atoms 331.0

Ring Count 12.0

Amide Bonds 38.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0235369 VERIFIED: YES

Provenance & Taxonomy

OrganismHeteroscodra maculata [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

DisulfideDisulfide bond(s) reported, sites unresolved

Bio-Activity Profile

Function

Toxin Potassium channel inhibitor

TargetKv2 voltage-gated potassium channels

Activity100-300 nM

MethodWhole-cell patch-clamp electrophysiology