Peptide Database

Peptide NameNeurotoxin BjTx-2

Function Ontology

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC113H183N35O41S6

DescriptionStandard

        VGCEECPAHCKGKNAIPTCDDGVCNCNV
    

Molecular Weight2880.26 Da

Isoelectric Point (pI)4.75

Net Charge (pH 7.0)-2.23

Net Charge (pH 7.4) -2.59

Charge Density (pH 7.0) -0.0797

GRAVY Index-0.17

Hydrophobic Moment 0.43

Boman Index0.01

Instability Index43.43

Aliphatic Index 52.14

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1210.86

LogP -17.06

H-bond Donors 44.0

H-bond Acceptors 46.0

Rotatable Bonds 91.0

Heavy Atoms 195.0

Ring Count 3.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0094177 VERIFIED: YES

Provenance & Taxonomy

OrganismButhotus judaicus,Hottentotta judaica [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideDisulfide bond(s) reported, sites unresolved

Bio-Activity Profile

Function

Toxin RyR1 activator

Targetryanodine receptor 1 (RyR1)

Activity20 μM

MethodEC50 ([3H]ryanodine binding assay)

RECORD: Rec_0209172 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-Term-

C-Term-

Bio-Activity Profile

Function

Toxic Cytotoxic