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MYP_011844
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Basic Information
Ranalexin-1Ca (Ranatuerin 1Ca; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
20 amino acids
C98H163N23O22S3
Standard
Sequence
FLGGLMKAFPALICAVTKKC
Physicochemical Analysis
2111.68 Da
9.39
2.74
2.50
0.1369
1.16
0.41
0.38
30.68
107.50
0.1000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.72
-2.86
26.0
28.0
69.0
146.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0169131 VERIFIED: YES
Provenance & Taxonomy
Rana clamitans [Animal]
Ranalexin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
14 μM
MIC
PaperPurification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.
RECORD: Rec_0186627 VERIFIED: YES
Provenance & Taxonomy
Lithobates clamitans [Animal]
Ranalexin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0217854 VERIFIED: YES
Provenance & Taxonomy
American green [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23053091 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23053091/
RECORD: Rec_0218644 VERIFIED: YES
Provenance & Taxonomy
Lithobates clamitans [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID10822101 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10822101/
RECORD: Rec_0234654 VERIFIED: YES
Provenance & Taxonomy
Lithobates calamitans [Animal]
Ranalexin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
14-20
Bio-Activity Profile
Antimicrobial Antifungal
PaperT. Halverson et al. / Peptides 21 (2000) 469-476. Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans Evidence URLhttps://www.uniprot.org/uniprotkb/P82876/entry
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