Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length589 amino acids

Chemical FormulaC2926H4619N755O829S18

DescriptionStandard

        MPRARSLTTPPPTPSSQAPLWRPLGLWPDRGGEPGNRRPVSSPSPAPTPVPSSFPHFTDLRFPSCLLHRSLVPLQGLEALAALEDEDMARGPDSTLRWATLVVLAALGTAVTANPNPGVVARITQKGLDYACQQGVTILQKELEKITIPPFSGSFKVKYLGKGQYSFYSMVIRGFKLPSSQIRPSPNQGLDLSIKDASIKISGKWKARKNFIKAKGNFDLSVEGISISAGLKLGYDPASGHSTVACSSCNSHINSVGLHISGSSLGWLIQLFHKKIESSLQNTMNSKVCEVVTSTVSSKLQPYFETLPVTVKLDNVAGIDYSLVAPPKAMADNLDVHLKGEVFSLAHRSPSPFAPPVLNLPTDHHLMVYLGISEYFFNTAGLVYQEAGVLNLTLKDDMIPKESKFHLTTNFFGTLIPQVAKMFPNMQVQLLIWASVPPHLTVCPTGLDIIFVLETQAFAVLPNSSLAPLFLLEMNTNVSVDVGARSDRLVGELKLNKLLLNLKHSDIGPFSVELLQMVMNYVLPTVVLPEINEEITLTSTLPLTSTFTSKAEKLQKGFPLPLPAYIQLFNLVLQPHQDFLLFGADVHFG
    

Molecular Weight64214.71 Da

Isoelectric Point (pI)8.55

Net Charge (pH 7.0)4.79

Net Charge (pH 7.4) 3.61

Charge Density (pH 7.0) 0.0081

GRAVY Index0.07

Hydrophobic Moment 0.67

Boman Index0.15

Instability Index45.98

Aliphatic Index 99.29

Aromaticity 0.0798

Extinction Coeff. Reduced 50880.00

Extinction Coeff. Oxidized 51255.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0285469 VERIFIED: NO

Provenance & Taxonomy

OrganismCamelus dromedarius [Animal]

FamilyBPI

Tax ID9838

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence