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MYP_011792
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Basic Information
Urotoxin (α-KTx 6.21)
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
37 amino acids
C161H267N51O51S9
Standard
Sequence
GDIKCSGTRQCWGPCKKQTTCTNSKCMNGKCKCYGCV
Physicochemical Analysis
4021.74 Da
9.06
5.67
5.34
0.1534
-0.68
0.44
-0.20
19.13
18.38
0.0541
6990.00
7490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1687.21
-24.62
67.0
66.0
136.0
272.0
4.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0431957 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
α-KTx-6
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human Kv1.2 potassium channel
190 pM
Kd
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
RECORD: Rec_0431958 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
α-KTx-6
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human KCa3.1 potassium channel
109 nM
Kd
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
RECORD: Rec_0431959 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
α-KTx-6
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human Kv1.4 potassium channel
Electrophysiological potassium-channel inhibition assay
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
RECORD: Rec_0431960 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
α-KTx-6
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human Kv1.5 potassium channel
Electrophysiological potassium-channel inhibition assay
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
RECORD: Rec_0431961 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
α-KTx-6
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human hERG1 potassium channel
Electrophysiological potassium-channel inhibition assay
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
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