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MYP_011792
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Basic Information
Urotoxin (α-KTx 6.21)
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
37 amino acids
C161H267N51O51S9
Standard
Sequence
GDIKCSGTRQCWGPCKKQTTCTNSKCMNGKCKCYGCV
Physicochemical Analysis
4021.74 Da
9.06
5.67
5.34
0.1534
-0.68
0.44
-0.20
19.13
18.38
0.0541
6990.00
7490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1687.21
-24.62
67.0
66.0
136.0
272.0
4.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0354659 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human Kv1.2 potassium channel
160 pM
IC50
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
RECORD: Rec_0431953 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
α-KTx-6
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human Kv1.1 potassium channel
253 nM
IC50
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
RECORD: Rec_0431954 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
α-KTx-6
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human Kv1.3 potassium channel
91 nM
IC50
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
RECORD: Rec_0431955 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
α-KTx-6
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human KCa3.1 potassium channel
70 nM
IC50
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
RECORD: Rec_0431956 VERIFIED: YES
Provenance & Taxonomy
Urodacus yaschenkoi [Animal]
α-KTx-6
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C-terminal amidation (Val37-NH2)
C-terminal amidation
Bio-Activity Profile
Potassium channel blocker; Ion channel inhibitor; Toxin
human Kv1.1 potassium channel
468 nM
Kd
PaperStructure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi PMID24723491
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