Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length178 amino acids

Chemical FormulaC898H1332N202O271S9

DescriptionStandard

        NLSGTDFFFFFIISDDAFQGIVYPGGNYSAPPFVAAPFTVPDQSDCMLYLAFSEYFFQTSSFAYYTAGAFNITIAEDVSRTCSYFNISTEIFGGIIPEVAQYSVTPYPVMLKLMATETPITSLQQDSFTLEIQGSMEVFAVLPDSSTQSLFTMSIAANTSIAVNIFDQKLMGSLCLNR
    

Molecular Weight19581.96 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-12.25

Net Charge (pH 7.4) -12.53

Charge Density (pH 7.0) -0.0688

GRAVY Index0.35

Hydrophobic Moment 0.56

Boman Index0.27

Instability Index49.62

Aliphatic Index 81.69

Aromaticity 0.1573

Extinction Coeff. Reduced 13410.00

Extinction Coeff. Oxidized 13535.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7478.32

LogP -77.12

H-bond Donors 256.0

H-bond Acceptors 268.0

Rotatable Bonds 615.0

Heavy Atoms 1380.0

Ring Count 38.0

Amide Bonds 193.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0288892 VERIFIED: NO

Provenance & Taxonomy

OrganismNothocercus nigrocapillus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria