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MYP_011699
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Basic Information
Ib-AMP4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C108H160N42O23S4
Standard
Sequence
QWGRRCCGWGPGRRYCRRWC
Physicochemical Analysis
2542.95 Da
10.66
5.72
5.46
0.2860
-1.39
0.69
-0.51
116.09
0.00
0.2000
17990.00
18240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1089.52
-10.67
47.0
33.0
77.0
177.0
8.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0116274 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Impatiens balsamina [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
6-16
Bio-Activity Profile
Antimicrobial Antifungal
Saccharomyces cerevisiae
13 μM
IC50
PaperA Novel Family of Small Cysteine-rich Antimicrobial Peptides from Seed of Impatiens balsamina Is Derived from a Single Precursor Protein
RECORD: Rec_0116862 VERIFIED: YES
Provenance & Taxonomy
Impatiens balsamina [Plant]
Impatiens family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
6-16; 7-20
N-terminal pyroglutamate
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic Cytotoxic Antifungal Anti-Gram-negative
Enterobacter cloacae
4月8日 μg/mL
MIC
PaperPubMed PMID 3713064 | PubMed PMID 2371306 | PubMed PMID 4000000 | Fan X et al., 2013 PMID3713064;2371306;4000000;37130642;37130;64000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3713064/
RECORD: Rec_0118901 VERIFIED: YES
Provenance & Taxonomy
Impatiens balsamina [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus oralis 35037
200 μg/mL
MIC
PMID30986507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30986507/
RECORD: Rec_0123131 VERIFIED: YES
Provenance & Taxonomy
Impatiens balsamina [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Cladosporium sphaerospermum
1 μg/mL
IC50
PaperPubMed PMID: 9305910 | PubMed PMID: 9454588 PMID9305910;9454588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9305910/
RECORD: Rec_0125908 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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