MYP_011578
Antimicrobial peptide NK-lysin
Anticancer
Anticancer
▸
Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antimicrobial
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Antibacterial
Antimicrobial
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Antibacterial
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Anti-Gram-negative
Antimicrobial
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Antibacterial
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Anti-Gram-positive
Antimicrobial
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Antifungal
Antiparasitic
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General antiparasitic
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Antiparasitic
Immunology
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Innate immune defense
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Host defense peptide
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Host defense activity
Toxicity / Safety
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Blood cell toxicity
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Hemolysis
▸
Hemolytic
Toxicity / Safety
▸
Cytotoxicity
▸
Cytotoxic
Venom / Toxin
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General toxin
▸
Cytotoxic
Standard
78 amino acids
C380H664N112O109S9
Standard
GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE
8834.61 Da
9.47
7.71
7.39
0.0989
-0.21
0.87
-0.14
36.01
97.44
0.0128
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
3628.03
-33.85
132.0
126.0
315.0
610.0
4.0
82.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0377921
VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Defensin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
Bacillus megaterium
0.8 μM
MIC
RECORD: Rec_0406197
VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-76, 7-70, 35-45
Bio-Activity Profile
Antimicrobial
Antibacterial
Antifungal
Anticancer
Escherichia coli Bd2221/75
10 μM
MIC
RECORD: Rec_0408663
VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-76, 7-70, 35-45
Bio-Activity Profile
Antimicrobial
Antibacterial
Antifungal
Anticancer
Cytotoxic
NK-lysin at 50μg/ml was able to give 90% lysis of 5'Cr-labelled YAC-1 cells in a medium with 2% fetal calf serum(FCS) and 75% lysis in phosphate-buffered saline(PBS), 15% lysis suspended in medium E
RECORD: Rec_0418798
VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-76, 7-70, 35-45
Bio-Activity Profile
Antimicrobial
Antibacterial
Antifungal
Anticancer
31 μM
MIC
Showing 4 records on this page · Page 5 of 5