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MYP_011578
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Basic Information
Antimicrobial peptide NK-lysin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
78 amino acids
C380H664N112O109S9
Standard
Sequence
GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE
Physicochemical Analysis
8834.61 Da
9.47
7.71
7.39
0.0989
-0.21
0.87
-0.14
36.01
97.44
0.0128
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3628.03
-33.85
132.0
126.0
315.0
610.0
4.0
82.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004340 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
4-76; 7-70; 35-45
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Host defense
PaperPDB 1NKL structural record; NMR; chain A; residues 1-78
RECORD: Rec_0014407 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
Escherichia coli
PaperNK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity.
RECORD: Rec_0044554 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-76, 7-70, 35-45
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer
Streptococcus pyogenes w
PMID7737114;9334742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7737114/
RECORD: Rec_0088014 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-76, 7-70, 35-45
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer
Escherichia coli D21
0.5 μM
MIC
PMID7737114;9334742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7737114/
RECORD: Rec_0122914 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-76, 7-70, 35-45
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer
Escherichia coli D21
8 μM
MIC
PMID7737114;9334742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7737114/
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