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MYP_011575
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Basic Information
Oncocin Onc112 [P12W, P13T], Onc289
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
19 amino acids
C114H179N37O26
Standard
Sequence
VDKPPYLPRPRWTRRIYNR
Physicochemical Analysis
2483.87 Da
11.45
4.73
4.52
0.2491
-1.66
0.54
-0.56
67.98
56.32
0.1579
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1044.35
-7.31
38.0
31.0
73.0
177.0
8.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0200778 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli MC4100
8 μg/mL
MIC
PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
RECORD: Rec_0295836 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: HepG2 (22% Killing=600 μg/ml)
PaperEffect of Amino Acid Substitutions on 70S Ribosomal Binding, Cellular Uptake, and Antimicrobial Activity of Oncocin Onc112. Chembiochem. 2022 Mar 4;23(5):e202100609. doi: 10.1002/cbic.202100609. PMID: 34902208. PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
RECORD: Rec_0340932 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa DSM1117
128 μg/mL
MIC
PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
RECORD: Rec_0390596 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC25922
8 μg/mL
MIC
PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
RECORD: Rec_0405699 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae DSM681
4 μg/mL
MIC
PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
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