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MYP_011561
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Basic Information
Ribonuclease 8 (1-45)[C23,37S]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
45 amino acids
C228H357N65O71S2
Standard
Sequence
KPKDMTSSQWFKTQHVQPSPQASNSAMSIINKYTERSKDLNTFLH
Physicochemical Analysis
5208.80 Da
9.70
2.93
2.62
0.0652
-1.04
0.51
-0.18
61.65
45.56
0.0889
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2238.79
-27.40
76.0
78.0
173.0
366.0
10.0
51.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0026543 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID31540052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31540052/
RECORD: Rec_0038417 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human acute monocytic leukemia THP-1
50 μM
IC50
PMID23962023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23962023/
RECORD: Rec_0043542 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID31540052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31540052/
RECORD: Rec_0085087 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID31540052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31540052/
RECORD: Rec_0116873 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028
10 μM
MFC
PMID23962023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23962023/
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