Peptide Database

Peptide NameMetastin

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide

Regulatory peptide ▸ Biological modulation

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length52 amino acids

Chemical FormulaC254H399N79O74S3

DescriptionStandard

        TSPCPPVENPTGHQRPPCATRSRLIPAPRGSVLVQREKDMSAYNWNSFGLRY
    

Molecular Weight5839.57 Da

Isoelectric Point (pI)9.83

Net Charge (pH 7.0)3.47

Net Charge (pH 7.4) 3.19

Charge Density (pH 7.0) 0.0667

GRAVY Index-0.81

Hydrophobic Moment 0.47

Boman Index-0.17

Instability Index58.70

Aliphatic Index 52.50

Aromaticity 0.0769

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2448.64

LogP -29.11

H-bond Donors 86.0

H-bond Acceptors 82.0

Rotatable Bonds 177.0

Heavy Atoms 410.0

Ring Count 14.0

Amide Bonds 56.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0131016 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyMetastin

Tax ID10116

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Disulfide4-18

Other Mods43:Phosphotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Reproductive regulator Receptor modulation

Half-LifeMammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0225035 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyKISS1

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsTyr43 Phosphotyrosine

Bio-Activity Profile

Function

Hormone Reproductive neuropeptide

RECORD: Rec_0281989 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/