Peptide Database

Peptide NameAtacicept

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length313 amino acids

Chemical FormulaC1552H2412N428O475S22

DescriptionStandard

        AMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSEPKSSDKTHTCPPCPAPEAEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPSSIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
    

Molecular Weight35371.77 Da

Isoelectric Point (pI)8.07

Net Charge (pH 7.0)3.53

Net Charge (pH 7.4) 2.47

Charge Density (pH 7.0) 0.0113

GRAVY Index-0.63

Hydrophobic Moment 0.64

Boman Index-0.09

Instability Index55.57

Aliphatic Index 61.60

Aromaticity 0.0863

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 46505.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0386135 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion protein

Tax ID32630

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory

RECORD: Rec_0431946 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion protein

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory BAFF/APRIL neutralization

TargetBLyS (BAFF); APRIL; BLyS/APRIL heterotrimer; TACI-transfected Jurkat cells; primary human B cells

MethodTACI-Jurkat signaling assay; primary human B-cell proliferation/neutralization assay

RECORD: Rec_0431947 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion protein

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Growth inhibition Immunomodulatory

TargetTACI-high primary myeloma cells; SCID-hu myeloma model

MethodSCID-hu in vivo tumor-growth assay; osteoclast coculture MTT growth-inhibition assay