Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length443 amino acids

Chemical FormulaC2251H3508N588O624S9

DescriptionStandard

        TSPGFVVRITQSGLDYAHQQGIAILEKELAQLKLPDISGDFRIRHVGKVHYEISRLDLRSFNLPYSRISLVPNVGLQVSISNAFAEVDGNWRVKIYFIRDHGSFDLKVENVYIKINLKLGSNAAGKPTIDTSDCSTRISKVRVHFWGKFGWLYNLFYGAVESRFRNILESKVCENVVTSVRSELQPYLQTLPVTARIDDKAGIDYSLVAPPTATAQSLDVDLKGEFFSLAHRSTVPFPPLALAFPPDHDRMVYFGASSYFFNTAGFAYHAAGALVFEITDSMIPKDTGFHLNTSTFSAFIPQLEKMYPDMPMKFRLSAPSAPFLNIGPGGLLFKPVVDIQAYAILPSSSLAPLFLLSLTSNVSAVIDVKSGHIVGNLTTGRYGVKALFLPPLSAPQVRMLQSLMNTIASLTLLPRLNERLAEGFPLPLPDRIQLSNILVRFHQ
    

Molecular Weight49080.08 Da

Isoelectric Point (pI)9.11

Net Charge (pH 7.0)6.37

Net Charge (pH 7.4) 5.50

Charge Density (pH 7.0) 0.0144

GRAVY Index0.10

Hydrophobic Moment 0.69

Boman Index0.13

Instability Index38.66

Aliphatic Index 100.36

Aromaticity 0.1061

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 38975.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0048548 VERIFIED: NO

Provenance & Taxonomy

OrganismHaliaeetus albicilla (White-tailed sea-eagle) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria