Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length422 amino acids

Chemical FormulaC2102H3359N575O602S16

DescriptionStandard

        MYLSIQPFSFSQYVYQPQTWQFMDEEKKRRTTYCSPSIKAKCEMMIVWCVLALLALVPVSTATNPGVKVKLTQKGLDYGRQLGVATLQQKFRTISIPDQSGKGKSFIGKVEYSLKGIRIVNLQLPTSTVGLVSGNGVRLSIDNANIKAQGNWRVKYRRFIKASGSFDLTVSGVTISVNIAVNNDNRGRPSVSMTSCTANLRDVNVRFSGRLSWLYNLFRSFIERPIRNSLRAQICPLVAKSIPDINAELATLNVVAKVDNYLEIDYSMLGSPLISSESIELGLKGVFYNIRQRNEPPFSAKPFSLPSQNTNMLYIGLSAFTVNSAAFAYHNAGAFSFDITDDLLGGLFARRRAVAELYPGLKMKLLVKTVKAPIITFEPNNVTVQISSTVMADVIHQNNTLSPLFMLNLVCHHEGRDGLSKT
    

Molecular Weight46830.69 Da

Isoelectric Point (pI)9.75

Net Charge (pH 7.0)19.80

Net Charge (pH 7.4) 19.21

Charge Density (pH 7.0) 0.0469

GRAVY Index-0.02

Hydrophobic Moment 0.91

Boman Index0.06

Instability Index40.74

Aliphatic Index 96.07

Aromaticity 0.0900

Extinction Coeff. Reduced 42860.00

Extinction Coeff. Oxidized 43235.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0144417 VERIFIED: NO

Provenance & Taxonomy

OrganismTriplophysa tibetana [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence