Peptide Database

Peptide NameSLAY-screened peptide P2198

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC97H151N29O33S

DescriptionStandard

        TYYPATNIRANNPLQSQNMS
    

Molecular Weight2283.48 Da

Isoelectric Point (pI)8.25

Net Charge (pH 7.0)0.40

Net Charge (pH 7.4) 0.20

Charge Density (pH 7.0) 0.0198

GRAVY Index-1.02

Hydrophobic Moment 0.25

Boman Index-0.14

Instability Index114.36

Aliphatic Index 49.00

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1040.46

LogP -14.55

H-bond Donors 34.0

H-bond Acceptors 35.0

Rotatable Bonds 70.0

Heavy Atoms 160.0

Ring Count 4.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0263987 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/