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MYP_011294
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Basic Information
Rev (34-50)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Standard
17 amino acids
C97H173N51O24
Standard
Sequence
TRQARRNRRRRWRERQR
Physicochemical Analysis
2437.74 Da
12.00
8.40
8.21
0.4942
-3.46
0.43
-1.60
207.80
5.88
0.0588
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1350.51
-17.82
54.0
33.0
87.0
172.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0138609 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 Bal | PM1-CCR5 cells
10 μM
EC50
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperRev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4. | Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M. | Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8. | DOI:10.1016/j.biocel.2010.05.005 | PMID:20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0292068 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
C-terminal Cystein amide labelled with fluorescein
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0313117 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Rev
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID11084031 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11084031/
RECORD: Rec_0333945 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0335215 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 IIIB
PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
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