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MYP_011281
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Basic Information
Cyclo(D-Pro-D-Phe), Diketopiperazine (pf)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
2 amino acids
C14H18N2O3
Standard
Sequence
PF
Physicochemical Analysis
262.30 Da
5.96
-0.04
-0.10
-0.0208
0.60
0.59
0.66
101.30
0.00
0.5000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
78.43
0.55
3.0
3.0
5.0
19.0
2.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0208896 VERIFIED: YES
Provenance & Taxonomy
Theobroma cacao [Plant]
3641
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Taste
RECORD: Rec_0296960 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID25821788 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821788/
RECORD: Rec_0309807 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0423130 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory ACE2 Inhibitory
ACE2
150.0
IC50
PaperGuy J. L., Jackson R. M., Acharya K. R., Sturrock E. D., Hooper N. M., Turner A. J.. Angiotensin-converting enzyme-2 (ACE2): comparative modelling of the active site, substrate specificity and chloride dependence. Biochemistry, 42, 13185-13192, 2003.
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