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MYP_011281
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Basic Information
Cyclo(D-Pro-D-Phe), Diketopiperazine (pf)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
2 amino acids
C14H18N2O3
Standard
Sequence
PF
Physicochemical Analysis
262.30 Da
5.96
-0.04
-0.10
-0.0208
0.60
0.59
0.66
101.30
0.00
0.5000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
78.43
0.55
3.0
3.0
5.0
19.0
2.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006482 VERIFIED: YES
Provenance & Taxonomy
Fungi [Fungus]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID29439550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29439550/
RECORD: Rec_0008869 VERIFIED: YES
Provenance & Taxonomy
Capra hircus [Animal]
9925.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-III Inhibitory
Dipeptidyl peptidase III
PaperDhanda S.; Singh H.; Singh J.. Hydrolysis of various bioactive peptides by goat brain dipeptidylpeptidase-III. Cell Biochem. Funct. 23, 3, 339-345, 2008.
RECORD: Rec_0020341 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]; Homo sapiens [Animal]
Casein-derived peptide
9913, 9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Taste Anti-inflammatory
180 μM
IC50
RECORD: Rec_0116379 VERIFIED: YES
Provenance & Taxonomy
Fungi [Fungus]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID29439550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29439550/
RECORD: Rec_0118221 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Model sensory peptide
32630
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
0.03 Rcaf
Relative bitterness (Rcaf)
PaperBitterness of phenylalanine- and tyrosine-containing peptides. Agric. Biol. Chem., 51, 3309-3313, 1987
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