Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length82 amino acids

Chemical FormulaC431H679N105O120S6

DescriptionStandard

        MCTKTIPVLWGCFLLWNLYISSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSK
    

Molecular Weight9444.02 Da

Isoelectric Point (pI)8.95

Net Charge (pH 7.0)2.48

Net Charge (pH 7.4) 2.21

Charge Density (pH 7.0) 0.0303

GRAVY Index-0.05

Hydrophobic Moment 0.68

Boman Index0.09

Instability Index36.40

Aliphatic Index 93.90

Aromaticity 0.1220

Extinction Coeff. Reduced 18450.00

Extinction Coeff. Oxidized 18575.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3644.00

LogP -26.85

H-bond Donors 128.0

H-bond Acceptors 129.0

Rotatable Bonds 317.0

Heavy Atoms 662.0

Ring Count 15.0

Amide Bonds 88.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0163887 VERIFIED: NO

Provenance & Taxonomy

OrganismPongo abelii [Bacterium]

FamilyBPI

Tax ID9601

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence