Peptide Database

Peptide NameCypemycin

Function Ontology

Anticancer

Anticancer ▸ Antitumor

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC95H157N23O29S2

DescriptionStandard

        TPATPTVAQFVIQGSTICLVC
    

Molecular Weight2149.53 Da

Isoelectric Point (pI)5.18

Net Charge (pH 7.0)-0.62

Net Charge (pH 7.4) -0.84

Charge Density (pH 7.0) -0.0296

GRAVY Index1.08

Hydrophobic Moment 0.33

Boman Index0.41

Instability Index24.28

Aliphatic Index 106.67

Aromaticity 0.0476

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 815.07

LogP -8.97

H-bond Donors 29.0

H-bond Acceptors 31.0

Rotatable Bonds 63.0

Heavy Atoms 149.0

Ring Count 3.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0268304 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces sp. [Bacterium]

FamilyBacteriocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anticancer Antitumor Anti-Gram-positive

TargetMouse P388 leukemia cells

Activity1.3 μg/mL

MethodIC50

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