Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length67 amino acids

Chemical FormulaC356H570N104O89S7

DescriptionStandard

        MKLLWLTVAALLLLTQLTPGGTQRCWNLHGKCRQKCSRRERTYVYCTNNKLCCVKPKFQPRENLWPF
    

Molecular Weight7955.43 Da

Isoelectric Point (pI)9.91

Net Charge (pH 7.0)9.53

Net Charge (pH 7.4) 9.16

Charge Density (pH 7.0) 0.1422

GRAVY Index-0.39

Hydrophobic Moment 0.48

Boman Index-0.11

Instability Index38.39

Aliphatic Index 80.00

Aromaticity 0.1045

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3153.72

LogP -26.40

H-bond Donors 117.0

H-bond Acceptors 107.0

Rotatable Bonds 260.0

Heavy Atoms 556.0

Ring Count 15.0

Amide Bonds 74.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0024616 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-stabilized linear peptide scaffold [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin

RECORD: Rec_0096098 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus dingo [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-stabilized linear peptide scaffold [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin

RECORD: Rec_0131140 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyDefensin

Tax ID9615

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KT1/entry; https://bblserver.org.in/ampdb/

RECORD: Rec_0145874 VERIFIED: NO

Provenance & Taxonomy

OrganismNyctereutes procyonoides (Raccoon dog) [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-stabilized linear peptide scaffold [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin

RECORD: Rec_0156692 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis familiaris [Animal]

FamilyDefensin

Tax ID9615

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial