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MYP_011002
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Basic Information
NBC2254
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
17 amino acids
C89H161N27O19S
Standard
Sequence
CALKLTKAKRLVRKIGF
Physicochemical Analysis
1945.46 Da
11.17
5.75
5.52
0.3380
0.19
0.86
-0.13
13.61
120.59
0.0588
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
777.03
-4.74
30.0
26.0
70.0
136.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0069944 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
methicillin-resistant Staphylococcus aureus (MRSA)
73±0.02 μM
MIC50
PMID31119600 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31119600/
RECORD: Rec_0086213 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
The sulfhydryl side chain of the cysteine residue was conjugated to AuNC(previously modified with SPDP) via a disulfide bond.
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
PMID31119600 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31119600/
RECORD: Rec_0093970 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
bovine blood cells
Hemolysis
PMID31119600 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31119600/
RECORD: Rec_0134102 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
The sulfhydryl side chain of the cysteine residue was conjugated to AuNC(previously modified with SPDP) via a disulfide bond.
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
Vero ATCC CCL-81 cells
93 %
Cell viability assay
PMID31119600 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31119600/
RECORD: Rec_0192581 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
The sulfhydryl side chain of the cysteine residue was conjugated to AuNC(previously modified with SPDP) via a disulfide bond.
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: MRSA
73±0.02 μM
MIC
PMID31119600 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31119600/
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