Peptide Database

Peptide NameLiraglutide

Function Ontology

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC162H246N42O51

DescriptionStandard

        HAEGTFTSDVSSYLEGQAAKEEFIIAWLVKGRG
    

Molecular Weight3597.94 Da

Isoelectric Point (pI)4.96

Net Charge (pH 7.0)-2.14

Net Charge (pH 7.4) -2.41

Charge Density (pH 7.0) -0.0650

GRAVY Index-0.19

Hydrophobic Moment 0.37

Boman Index0.11

Instability Index24.30

Aliphatic Index 76.97

Aromaticity 0.1212

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1503.90

LogP -14.40

H-bond Donors 53.0

H-bond Acceptors 50.0

Rotatable Bonds 119.0

Heavy Atoms 255.0

Ring Count 6.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0008011 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]

FamilyGLP-1 receptor agonist peptide

Tax ID9606;4932

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical or chemical modification [Modified]

Other ModsLys26 γ-Glu-C16 fatty-acid acylation; Lys34→Arg substitution

Bio-Activity Profile

Function

Antidiabetic Hypoglycemic GLP-1 receptor agonist

Half-Lifeapprox. 13 h

PaperPubMed-linked source references: PMID:25656058; PMID:25650514; PMID:25626486; PMID:25625650; PMID:25619391; PMID:25614699; PMID:20709939; PMID:19343230; PMID:19041364 PMID25656058;25650514;25626486;25625650;25619391;25614699;20709939;19343230;19041364 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25656058/ PatentCA2264243