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MYP_010952
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Basic Information
Esculentin-2ISa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
37 amino acids
C169H295N45O49S3
Standard
Sequence
GIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC
Physicochemical Analysis
3837.62 Da
9.51
3.74
3.50
0.1011
0.36
0.67
0.15
-3.85
102.97
0.0270
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1528.97
-14.87
55.0
56.0
136.0
266.0
1.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0065231 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
12.5 μM
MIC
PaperE. Iwakoshi-Ukena et al. / Peptides 32 (2011) 670-676. Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae PMID21193000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21193000/
RECORD: Rec_0071250 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Esculentin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 6538
3.1 μM
MIC
PMID21193000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21193000/
RECORD: Rec_0084964 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
31-37
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
100 μM
MIC
PaperIdentification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae
RECORD: Rec_0103041 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
100 μM
MIC
PMID21193000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21193000/
RECORD: Rec_0108083 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus (MRSA)
25 μM
MIC
PMID21193000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21193000/
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