Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length448 amino acids

Chemical FormulaC2205H3518N612O616S12

DescriptionStandard

        ARQYGVAILEQELHQLRLPDISGDFRVRRVGKVHYELSSLSLRSFHLPSSQISPIPNVGLQVSISDASAVVEGNWRVKLHFIRDHGTFDLKVEDLSISIGLKLGNDSSGKPTADVSSCSTHISSVRVHFSGRFSWLYNLFHSAIDSVFRRTLERQVCERVVSSVRDELQSYLRTLPGQARVTGAVGKPVCPAALTALARGGARGLPGPSAAVPTLQGEFFSLARHSAVPFSPPPLALPPDRARMVYFGASSYFFNTAGLVYHTAGALVFELTDSMIPKGLEFHLNTSTFSAFVPQLEKMYPDMLMKLRLSTPAAPFLSIGPEGLSLQPVVDIQAYAILPSSSLAPLFLLNLVSRARLVVLPAGVLARCLSCVPMAVASSADTLSLPQVRTLQSVMNILTSSILLPRFNARLAQGFPLPLLDRIQLSNVLVQWHQNLLLLGADVHLQRR
    

Molecular Weight48842.03 Da

Isoelectric Point (pI)9.67

Net Charge (pH 7.0)11.92

Net Charge (pH 7.4) 10.94

Charge Density (pH 7.0) 0.0266

GRAVY Index0.20

Hydrophobic Moment 0.70

Boman Index0.12

Instability Index49.11

Aliphatic Index 106.63

Aromaticity 0.0759

Extinction Coeff. Reduced 29910.00

Extinction Coeff. Oxidized 30160.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0319500 VERIFIED: NO

Provenance & Taxonomy

OrganismTinamus guttatus [Animal]

FamilyBPI/LBP

Tax ID94827

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria