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MYP_010826
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Basic Information
Antimicrobial peptide, Metchnikowin A1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
26 amino acids
C137H201N43O36
Standard
Sequence
HRHQGPIFDTRPSPFNPNQPRPGPIY
Physicochemical Analysis
3026.33 Da
10.74
1.93
1.63
0.0744
-1.45
0.29
-0.21
63.02
30.00
0.1154
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1242.70
-13.30
39.0
40.0
84.0
216.0
12.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0280237 VERIFIED: YES
Provenance & Taxonomy
Drosophila sechellia [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0325959 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
7227; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Host defense
PaperPDB 4EZS structural record; X-ray; 1.90 A; chain B; residues 20-26
RECORD: Rec_0326740 VERIFIED: YES
Provenance & Taxonomy
Fruit fly [Animal]; Insecta [Animal]
33208; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID8002963 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8002963/
RECORD: Rec_0344194 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Metchnikowin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Micrococcus luteus
0.5-1.0 μM
MIC
PMID7588819 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7588819/
RECORD: Rec_0364718 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Neurospora crassa
0.5-1 μg/mL
MIC
PMID7588819 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7588819/
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