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MYP_010826
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Basic Information
Antimicrobial peptide, Metchnikowin A1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
26 amino acids
C137H201N43O36
Standard
Sequence
HRHQGPIFDTRPSPFNPNQPRPGPIY
Physicochemical Analysis
3026.33 Da
10.74
1.93
1.63
0.0744
-1.45
0.29
-0.21
63.02
30.00
0.1154
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1242.70
-13.30
39.0
40.0
84.0
216.0
12.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0061394 VERIFIED: NO
Provenance & Taxonomy
Drosophila melanogaster [Animal]
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0127987 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
PrAMP
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
N. crassa
0.5-1.0 μM
MIC
PaperMetchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties.
RECORD: Rec_0137857 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperLevashina E.A., Ohresser S., Lemaitre B., Imler J.-L.;. "Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin."; J. Mol. Biol. 278:515-527). Evidence URLhttps://www.uniprot.org/uniprotkb/MTK_DROME/entry
RECORD: Rec_0178395 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Metchnikowin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
N.crassa
0.5-1.0 μM
MIC
PMID7588819 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7588819/
RECORD: Rec_0184480 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Micrococcus luteus
0.5-1 μg/mL
MIC
PMID7588819 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7588819/
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