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MYP_010716
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Basic Information
B1AW
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C123H205N31O27S2
Standard
Sequence
FLPLLAGLAANFLPQIICKIARKC
Physicochemical Analysis
2614.26 Da
9.50
2.74
2.50
0.1141
1.14
0.77
0.35
23.86
146.67
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
915.16
-3.35
32.0
32.0
84.0
183.0
4.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0336137 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Amolops wuyiensis [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Anticancer
Candida albicans ATCC 10231
>512 μM
MIC
PaperDiscovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue.
RECORD: Rec_0343875 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Amolops wuyiensis [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Anticancer
Enterococcus faecalis NCTC 12697
32 μM
MIC
PaperDiscovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue.
RECORD: Rec_0384266 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Amolops wuyiensis [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Anticancer
but was unable to disrupt biofilms
>256 μM
MBEC
PaperDiscovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue.
RECORD: Rec_0385459 VERIFIED: YES
Provenance & Taxonomy
Amolops wuyiensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0399701 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID37228702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37228702/
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