Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2336H3733N595O673S23

DescriptionStandard

        MMFLWCLLVLVNLVLVSTSNNAGVEVRLTQKALEYGRQIGITSIQQKLRSMKVPDISGTEKVDPIGKVQYSFTGMQIVNLGLPKSALGLVPDTGVMLSIGQAYISLHGNWRVKYLRIIKDSGSFDLAVGELAISTTIAVMSDDTGRPTVSMTNCAATVGSVNVKFHGGASWLYNLFSSFINKALRSALQKQICPLVADSIAEMNPHLKTLNVLAKVDQYAEIDYSMVGSPVISNTSIDLGLKGEFYNIGQHKEPPFSPTPFSLPYQDTNMLYIGVSAFSLNSAGFVYHNAGALRLYITDDMIPSGSPIRLNTRTFGAFIPQIAKMYPGLMMKLLVETVKEPIIIFEPNNMTIQASSTVTAYAIQPNSTLSSLFVLNLEGSVSANIHVTELKLAGNVTLNKMFMSLAKSYVGPFQVTSLDNIFSMVLKVAVIPKINARLQEGYPLPAIGKMQLVNSQLQVLKDYLLIGTDVQFMG
    

Molecular Weight51658.70 Da

Isoelectric Point (pI)8.85

Net Charge (pH 7.0)5.01

Net Charge (pH 7.4) 4.35

Charge Density (pH 7.0) 0.0106

GRAVY Index0.25

Hydrophobic Moment 0.71

Boman Index0.19

Instability Index32.30

Aliphatic Index 105.68

Aromaticity 0.0823

Extinction Coeff. Reduced 41830.00

Extinction Coeff. Oxidized 41955.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0170905 VERIFIED: YES

Provenance & Taxonomy

OrganismMegalobrama amblycephala [other]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria