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MYP_010685
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WWVXAFAXRRR
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0331639 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 4,8
Bio-Activity Profile
Hemolytic
Human erythrocytes
4.49 μM
Hemolysis
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0355928 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Amidation
①The X (position: 4 and 8) in sequence are (S)-2-(4'-pentenyl)-alanine. ②X (4) and X (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Hemolytic
human red blood cells
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0373072 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Amidation
①The X (position: 4 and 8) in sequence are (S)-2-(4'-pentenyl)-alanine. ②X (4) and X (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Candida albicans 004 ATCC MYA-2876
20 μM
IC50
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0378295 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Amidation
①The X (position: 4 and 8) in sequence are (S)-2-(4'-pentenyl)-alanine. ②X (4) and X (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Escherichia coli ATCC 700926
1.34 μM
IC50
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0406361 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 4,8
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Bacillus megaterium ATCC 14581
5 μM
MIC
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
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