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MYP_010640
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Basic Information
DV1
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
29 amino acids
C143H210N34O38
Standard
Sequence
AWDFGSIGGVFTSVGKLVHQVFGTAYGVL
Physicochemical Analysis
3013.40 Da
6.79
-0.12
-0.36
-0.0041
0.81
0.59
0.47
-5.93
97.24
0.1724
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1130.15
-8.80
40.0
39.0
93.0
215.0
7.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019721 VERIFIED: YES
Provenance & Taxonomy
Dengue virus 1 [Virus]
Virus-derived peptide
11053;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 1 virus (Virus entry); BHK-21
1.5 μM
IC90
PaperPeptide inhibitors of flavivirus entry derived from the E protein stem. | Schmidt AG, Yang PL, Harrison SC. | J Virol. 2010 | PMID:20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0020312 VERIFIED: YES
Provenance & Taxonomy
Dengue virus 2 [Virus]
Virus-derived peptide
11060;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 2 virus (Virus entry); BHK-21
6 μM
IC90
PaperPeptide inhibitors of flavivirus entry derived from the E protein stem. | Schmidt AG, Yang PL, Harrison SC. | J Virol. 2010 | PMID:20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0032204 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-3
>6 μM
IC90
PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0043025 VERIFIED: YES
Provenance & Taxonomy
Dengue virus 1 [Virus]
Virus-derived peptide
11053;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 1 virus (Virus entry); BHK-21
5 μM
IC90
PaperPeptide inhibitors of flavivirus entry derived from the E protein stem. | Schmidt AG, Yang PL, Harrison SC. | J Virol. 2010 | PMID:20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
RECORD: Rec_0047260 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
Dengue 2 virus (DENV2) | BHK-21 cells
2 μM
IC90
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide inhibitors of flavivirus entry derived from the E protein stem. | Schmidt AG, Yang PL, Harrison SC. | J Virol. 2010 Dec;84(24):12549-54. | DOI:10.1128/JVI.01440-10 | PMID:20881042 PMID20881042 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20881042/
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