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MYP_010618
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Basic Information
Esculentin-1-OA2 (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
46 amino acids
C219H366N60O59S3
Standard
Sequence
GLFSKFSGKGIKNFLIKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC
Physicochemical Analysis
4879.81 Da
9.63
4.83
4.53
0.1049
0.13
0.71
0.11
-0.64
95.22
0.0652
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1924.54
-16.57
69.0
68.0
175.0
341.0
4.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0154790 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
40-46
Bio-Activity Profile
Antimicrobial Antifungal
PaperX. Yang et al. / Journal of Proteome Research 11 (2012) 306-319. Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0166337 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
1.3 μg/mL
MIC
PaperExtremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0174275 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Esculentin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
1.3 μg/mL
MIC
PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0198861 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
2.5 μg/mL
MIC
PaperExtremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0215634 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli ATCC 25922
2.5 μg/mL
MIC
PaperExtremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. PMID: 22029824. PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
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