Peptide Database

Peptide NameBeta-insect excitatory toxin BmK IT-AP

Function Ontology

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length72 amino acids

Chemical FormulaC359H544N88O113S8

DescriptionStandard

        KKNGYAVDSSGKVAECLFNNYCNNECTKVYYADKGYCCLLKCYCFGLADDKPVLDIWDSTKNYCDVQIIDLS
    

Molecular Weight8157.20 Da

Isoelectric Point (pI)4.77

Net Charge (pH 7.0)-2.32

Net Charge (pH 7.4) -2.67

Charge Density (pH 7.0) -0.0322

GRAVY Index-0.26

Hydrophobic Moment 0.48

Boman Index0.01

Instability Index34.37

Aliphatic Index 74.44

Aromaticity 0.1389

Extinction Coeff. Reduced 15930.00

Extinction Coeff. Oxidized 16430.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3282.20

LogP -31.28

H-bond Donors 119.0

H-bond Acceptors 119.0

Rotatable Bonds 268.0

Heavy Atoms 568.0

Ring Count 12.0

Amide Bonds 78.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0426973 VERIFIED: YES

Provenance & Taxonomy

OrganismMesobuthus martensii [Animal]

FamilySodium channel inhibitor family

Tax ID34649; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide16-37; 22-42; 26-44; 38-64

Bio-Activity Profile

Function

Toxin Venom Sodium channel inhibitor family Ion channel inhibitor Host defense