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MYP_010576
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Basic Information
RGD-Las
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C88H152N26O21
Standard
Sequence
RGDLLRHVVKILSKYL
Physicochemical Analysis
1910.31 Da
10.28
2.85
2.59
0.1778
0.13
0.79
-0.06
33.08
158.12
0.0625
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
782.10
-3.99
29.0
25.0
66.0
135.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0068518 VERIFIED: YES
Provenance & Taxonomy
Arg-Gly-Asp [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
BGC-823 (73.705 Inhibition ratio at 50 μg/ml)
PaperPubMed PMID: 22641352 PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0123112 VERIFIED: YES
Provenance & Taxonomy
Arg-Gly-Asp [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HL-7702(L-02) (38.13 Inhibition ratio at 50 μg/ml)
PaperPubMed PMID: 22641352 PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0125507 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
RGD-modified temporin analogs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
HepG-2 (liver cancer)
50 μg/mL
MTT/MTS assay
PaperDesigned synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain | https://pubmed.ncbi.nlm.nih.gov/22641352/ PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0133311 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
HeLa
50 μg/mL
Inhibition
PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0156763 VERIFIED: YES
Provenance & Taxonomy
Arg-Gly-Asp [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HeLa (78.045 Inhibition ratio at 50 μg/ml)
PaperPubMed PMID: 22641352 PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
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