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MYP_010500
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Basic Information
Brevinin-1Sc
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C123H201N29O29S2
Standard
Sequence
FFPIVAGVAGQVLKKIYCTISKKC
Physicochemical Analysis
2614.22 Da
9.60
3.74
3.50
0.1556
0.82
0.63
0.29
17.44
109.58
0.1250
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
931.69
-5.04
34.0
35.0
86.0
183.0
4.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0081189 VERIFIED: YES
Provenance & Taxonomy
Lithobates sphenocephalus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
14.0 μM
MIC
PaperJ.M. Conlon et al. / J. Peptide Res. 54 (1999) 522-527. Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala Evidence URLhttps://www.uniprot.org/uniprotkb/P82906/entry
RECORD: Rec_0125960 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0151174 VERIFIED: NO
Provenance & Taxonomy
Rana sphenocephala [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 7862826 B2 Evidence URLhttps://patents.google.com/patent/US7862826B2/en PatentUS 7862826 B2
RECORD: Rec_0203794 VERIFIED: YES
Provenance & Taxonomy
Rana sphenocephala [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
14 μM
MIC
PMID10604597 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10604597/
RECORD: Rec_0217039 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
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