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MYP_010390
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Binding / Molecular interaction ▸ Binding activity
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Lipoxygenase Inhibitory
Hemostasis ▸ Anticoagulant activity
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
7 amino acids
C38H59N11O10
Standard
Sequence
AVPYPQR
Physicochemical Analysis
829.94 Da
8.79
0.79
0.61
0.1136
-0.93
0.50
-0.17
81.23
55.71
0.1429
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
345.56
-2.53
11.0
11.0
21.0
59.0
3.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0341966 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory Dna-Synthesis Stimulating Anticoagulant Antioxidant Antimicrobial Antibacterial ACE inhibitory
Angiotensin-converting enzyme
15 μM
IC50
RECORD: Rec_0349659 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Bradykinin-potentiating peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory Bradykinin-potentiating
ACE
15 μM
IC50
PaperA peptide inhibitor of angiotensin 1-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein II. Isolation and bradykinin-potentiating activity on the uterus and ileum of rats
RECORD: Rec_0362567 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Binding
HeLa
PaperMiao J., Liao W., Pan Z., Wang Q., Duan S., Xiao S., Yang Z., Cao Y.. Isolation and identification of iron-chelating peptides from casein hydrolysates. Food Funct., 22, 2372-2381, 2019.
RECORD: Rec_0370810 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
10 mmHg
SBP decrease
PaperAntihypertensive peptides: production, bioavailability and incorporation into foods. PMID21185549 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185549/
RECORD: Rec_0397348 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperCaseins and Casein Hydrolysates 2 Antioxidative Properties and Relevance to Lipoxygenase Inhibition | Rival, S. et al. | DOI: 10.1021/jf0003911 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
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