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MYP_010390
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Binding / Molecular interaction ▸ Binding activity
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Lipoxygenase Inhibitory
Hemostasis ▸ Anticoagulant activity
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
7 amino acids
C38H59N11O10
Standard
Sequence
AVPYPQR
Physicochemical Analysis
829.94 Da
8.79
0.79
0.61
0.1136
-0.93
0.50
-0.17
81.23
55.71
0.1429
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
345.56
-2.53
11.0
11.0
21.0
59.0
3.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0172622 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
15 μM
IC50
PaperAngiotensin I-Converting Enzyme Inhibitor Derived from an Enzymatic Hydrolysate of Casein II Isolation and Bradykinin-potentiating Activity on the Uterus and the Ileum of Rats | Maruyama, S. et al. | DOI: 10.1080/00021369.1985.10866901 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0197844 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Gram-negative bacteria
MIC
PaperIsolation and identification of some antibacterial peptides in the plasmin-digest of β-casein | Sedaghati, H. et al. | DOI: 10.1016/j.lwt.2015.12.019 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0219821 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
99130
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antithrombotic
Thrombin
PaperSequence analysis and molecular docking of antithrombotic peptides from casein hydrolysate by trypsin digestion. Journal of Functional Foods 32:313-323 (2017). DOI: 10.1016/j.jff.2017.03.015.
RECORD: Rec_0255823 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
ACE-inhibitory peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
10 mmHg
SBP decrease
PaperAntihypertensive Peptides Specific to Lactobacillus helveticus Fermented Milk
RECORD: Rec_0259197 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Osteoanabolic
Epidermal growth factor receptor
PaperPreparation, identification and screening of anti-osteoporosis milk-derived peptides: intervention effects in osteoporosis rats. Food Bioscience 62:105120 (2024). DOI: 10.1016/j.fbio.2024.105120.
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