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MYP_010339
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Basic Information
Brevinin-1VLe
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C126H205N27O27S2
Standard
Sequence
FLPLIAGVAASILPKIFCFITKKC
Physicochemical Analysis
2594.27 Da
9.39
2.74
2.50
0.1141
1.48
0.57
0.49
30.12
138.33
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
833.56
-1.42
30.0
32.0
82.0
182.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0283238 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
3000 μM
MIC
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
RECORD: Rec_0317530 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 29.2%, E 8.3%, T 29.2%, C 33.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0334373 VERIFIED: YES
Provenance & Taxonomy
Rana vaillanti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
100 μM
MIC
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
RECORD: Rec_0342998 VERIFIED: YES
Provenance & Taxonomy
Rana vaillanti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
RECORD: Rec_0361847 VERIFIED: YES
Provenance & Taxonomy
Rana vaillanti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
3 μM
MIC
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
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